uhhh, not sure why anyone would go thru globe if you are in mesa. Pretty much nobody goes that route. It's longer and if you go thru globe, you have to drive WAY past Roosevelt Lake resort, which is pretty far from even Windy hill boat ramp. Just head down Ellsworth or Power Road and keep on going past Saguaro Lake until you hit the B-line.
There is a gas station at Jakes corner and another one before you hit Punkin Center.
As far as I know, most people head up the B-line highway like "Solo" explains. I have driven both ways and live in Mesa. It took my 2 hours when I took the Globe route. However, if I take the B-line route, thru the mountains, it always takes us about 1 hour 20 minutes. Of course, that includes the stop at Jakes Corner to get beer!
We are driving up with 2 boats on Sunday (mine & black Moomba Gravity games edition). The winds will be low and it will be awesome out. Flag us down.
Launch at Cholla ramp. The water always seems better at that end.