I would say RBs are going to be at a premium this year.... If you have a flex spot I would suggest trying to get a RB there too. If you can have at least 3, but 4+ solid RB choices and they stay healthy, you'll have a ton of trade power too.
.... its common sense, but try and draft guys that don't share the running load with another back.
There are plenty of solid QB options, you could honestly put this on the back burner until 5/6+ rounds
Also having a TE / Def (obscure positions) that can consistently bring you points is really helpful. Don't be afraid to deviate from the ESPN / YAHOO / ETC rankings to grab a solid Defense or TE.
....also its super hard to not like your favorite team sway your decision (or the team you hate).... don't reach for a player on a team you love or let someone good slip by because you hate the team they are on.