That is a difficult decision between the Pro485 and REV10s because they are both excellent products.
The Wetsounds Pro485 has more low frequency reach in the treble from a more substantial horn with a larger diaphragm. You are going to get only so many octaves from any midbass driver and the 8-inch midbass drivers from the Pro485 have the upper midrange reach to integrate well with the horn. This is a 'linear' (little in the way of unwanted peaks or valleys) speaker with upfront midrange. It has the linearity, purity and balance similar to two pair of REV8s. Although, the Pro485 has stronger midbass than another four 8"s due to more pod displacement. If the Pro485 were to stay in the Wetsounds line-up just as is it would be successful for a very long time.
The Wetsounds REV10, with a larger 10-inch midbass driver, has deeper bass extension. The REV10 has midrange that is slightly recessed by comparison. The REV10 has a little extra kick in the upper treble, which is more in the percussion and upper harmonics area and well above the vocal range. Other than this slight accentuation of the upper highs this speaker has no peaks or bumps in the response. Frankly, this is a popular sound for many who try to create this curve with their EQ. Its a matter of subtle tonal distinctions but what differentiates these two speakers. If you put more power to two pair of REV10s there is no question that the greater surface produces a more dynamic speaker.
I probably haven't made the choice any easier but those are the clinical differences. There isn't another tower speaker on the market that I could recommend over these two choices.