We don't carry, but have both taken the course and shoot during certain times of the year. We were newb's to guns until a couple of years ago. I would like to carry, but b/c of my job, I cannot so I feel it would not become second nature to have the weapon. Anyway, we have looked at several weapons and rented some too. She tried the LCP and it was not comfortable (along with some others), plus all the 380 stuff is expensive and hard to find. If you don't/want to shoot, you'll never get good with it. That's when we tried a Glock G26. It's a 9mm, fit her hand well and was easy to shoot. We had planned to get one and maybe still will. It's just on hold for little while. I would highly suggest having your wife try the G26. It's a subcompact and called the "Baby Glock", but is still big enough for me to comfortably shoot. Sounds like it's right up her/yours alley.
Oh, I should probably say that I am not a Glock kool-aid drinker. I have several brands. Good luck on your pistol purchase.