i was on the 405 yesturday on my way to Disneyland in cali and it was pitch black. The LA skyline was insane. All of the skyscrapers were lit up and the traffic lights were perfect. But I could not get the picture to capture the lights it was all blurry
Cranking up the ISO for night/skyline shots just wipes them out so I like to stick to under ISO400 and thus a tripod is really a must (or set the cam down on something)
Turn off IS, engage MLU and set the shutter mode for 2 or 10 second timer. Let the camera set the shutter in AV mode initially and then adjust to taste after looking at the image in the LCD. I've found it will usually overexpose a bit.