Speakers Popping?????

I've got a pair of PRO80's and 1 JL sub and 2 PPI4125 powering everything. Here recently after getting the Pro80's hooked up and changing some things around I noticed some high pitched fuzz sound as well as "popping" when advancing through tracks on cd's or changing radio stations. In the past I've dealt with the whine in having power wires and component wires to close to each other. But with this most recent change of things I've actually moved power wires in a more straight shot from the batteries and the speaker wires/ component wires stay on the other end of the amp. Sorry for such a long post, has anyone dealt with a similar problem?