If it's a holley 4150 or 4160 4 barrell, you need a vaccum gauge to adjust these. To use the gauge, turn both screws all the way until tight, back each screw out 1.5 turns. With vaccum gauge connected, the engine running at idle or less than 700 rpm, turn one screw all the way, and turn it out slowly. You want to get the most vaccum possible, but with the needle not bouncing around.... steady... once done, repeat on the other side. The mixture screws are only good for adjusting the engine between Idle and about 2500 RPM.s after that, it's a timing issue. If the screws are all the way out, you probably have a leak somewhere.. or the carb is severly worn. What type of boat or engine do you have? I just replaced my whole carb on my Nautique 84' with larger carb for the hungry 351 Ford... It runs much better now...had to redo a lot of things, fuel lines, timing, etc... but once done... it screams now...
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