I got a kick out the Chris dating a Down Syndrome girl.
I also got a kick out of Palin getting her panties in a bunch over it. Not really sure what all the hype is about, but if you watch it you can see that they clearly have the DS girl very empowered.
Here is a clip: http://www.huffingtonpost.com/2010/02/15/family-guy-trig-palin-vid_n_462522.html
If you have the time, watch the full episode, it is hysterical.